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. Author manuscript; available in PMC: 2014 May 1.
Published in final edited form as: FEBS J. 2013 Feb 6;280(10):2399–2417. doi: 10.1111/febs.12109

Figure 2. Proteoglycan and proteoglycan-modifying enzyme gene expression is altered in GBM.

Figure 2

The mean expression of a number of proteoglycan core protein genes (A) and proteoglycan-modifying enzymes (B) are altered in GBM relative to non-neoplastic controls. Bars represent the mean log2(Tumor/Normal) ratio +/− SEM gene expression from n=424 primary GBM. TCGA Data Portal [122]; http://cancergenome.nih.gov. Proteoglycan genes include HSPGs (blue); CSPGs (red); and part-time proteoglycans or those commonly modified by KS and DS (white). Enzymes in (B) include those common to both CSPG and HSPG biosynthesis (Com), HSPG biosynthetic enzymes (blue), and CSPG biosynthetic enzymes (red) including those involved in chain elongation and sulfation. The plasma membrane associated and the extracellular enzymes (PM/ECM) include HPSE, extracellular SULFs and HAS family members. For gene names and more information on the proteoglycan core proteins and enzymes, please refer to GeneCards at http://www.genecards.org/. For reviews on proteoglycan synthesis see [176]: HSPG [24]; CSPG [25]; SULF [8]; HPSE [100]; HAS [141]