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Summary of dose-limiting toxicities during the first treatment cycle
| Treatment | Dose-limiting toxicity | ||
|---|---|---|---|
| Afatinib dose (mg/day) | Docetaxel dose (mg/m2) | CTCAE grade | Treatment cycle |
| 120 | 75 | Grade 4 febrile neutropenia | 1 |
| 120 | 75 | Grade 3 vomiting and diarrhea | 1 |
| 160 | 75 | Grade 4 neutropenia | 1 |
