Table 2.
Biodistribution of [18F]9b in BALB/c mice with subcutaneous DBT tumors. Mice were anesthetized with 1% isoflurane/oxygen and 20–30 μCi (0.74 – 1.1 MBq) of [18F]9b was administered via tail vein injection. The animals were euthanized in groups of 4 animals at 5, 30 and 60 minutes post injection.
5 min | 30 min | 60 min | |
---|---|---|---|
| |||
blood | 4.06 ± 0.35 | 0.44 ± 0.07 | 0.15 ± 0.04 |
bone | 1.08 ± 0.11 | 0.42 ± 0.05 | 0.30 ± 0.06 |
brain | 0.24 ± 0.08 | 0.08 ± 0.01 | 0.04 ± 0.01 |
fat | 1.12 ± 0.32 | 0.17 ± 0.11 | 0.09 ± 0.04 |
heart | 2.29 ± 0.16 | 0.67 ± 0.05 | 0.27 ± 0.15 |
kidney | 18.09 ± 1.46 | 2.07 ± 0.37 | 0.55 ± 0.07 |
liver | 4.12 ± 0.33 | 0.49 ± 0.04 | 0.17 ± 0.02 |
lung | 3.66 ± 0.23 | 0.44 ± 0.07 | 0.13 ± 0.01 |
muscle | 1.52 ± 0.17 | 0.66 ± 0.04 | 0.34 ± 0.09 |
pancreas | 8.90 ± 0.96 | 1.08 ± 0.18 | 0.23 ± 0.07 |
salivary gland | 2.29 ± 0.17 | 0.30 ± 0.03 | 0.10 ± 0.02 |
spleen | 2.77 ± 0.14 | 0.93 ± 0.73 | 0.17 ± 0.03 |
thyroid | 2.23 ± 0.29 | 0.51 ± 0.05 | 0.20 ± 0.03 |
tumor | 2.05 ± 0.48 | 0.90 ± 0.16 | 0.42 ± 0.16 |
The data are expressed as %ID/g with the exception of the thyroid which is expressed as %ID/organ. Error is expressed as standard deviation. n = 3 or 4 for each value.