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. 2013 Apr 23;14:275. doi: 10.1186/1471-2164-14-275

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Copyright © 2013 Dosanjh et al.; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Integrin pathway molecules identified by the analysis of statistically significant genes between subjects without CAN/IFTA vs. those with CAN/IFTA. Genes in grey are differentially expressed whereas genes in white are not significantly differentially expressed. It is evident that most genes of the integrin pathway are differentially expressed in CAN/IFTA. The genes that are marked with thick arrows were differentially expressed both at the mRNA level as well as at the protein level by tandem mass spectroscopy proteomics. Protein levels were estimated in this study by using the accumulation of spectral counts for each detected protein as we have previously published [31].