Timeline.
IL-1-blocking agents in various disease states
The timeline highlights the testing of interleukin-1 (IL-1)-blocking agents in various but not all indications. AOSD, adult-onset Still’s disease; CANTOS, Canakinumab Anti-inflammatory Thrombosis Outcome Study; CAPS, cryopyrin-associated periodic syndrome; FMF, familial Mediterranean fever; HIDS, hyper-IgD syndrome; MWS, Muckle–Wells syndrome; SJIA, systemic juvenile idiopathic arthritis; STEMI, ST segment elevation myocardial infarction; TRAPS, TNF receptor-associated periodic syndrome.