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Haplotypes and the missense mutations in 4 PTC families. A unique haplotype (boxed) cosegregates with the PTC phenotype in each family. Solid circles or squares, Individuals affected with PTC. Hatched symbols, Individuals affected with benign thyroid disease (benign nodule or goiter). DNA samples of individual 2 in family 20 and individuals 2 and 3 in family 13 were not available for haplotype analysis.
