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Effect of treatment with M22 (100 μg/mL) with or without 1 or 2 (10 μM each) on cAMP production (A), phosphorylation of Akt (B), or HA production (C) in undifferentiated GO orbital fibroblast cultures (n = 6). Results are expressed as mean ± SEM fold change relative to control cultures or to parallel M22-treated cultures. *P < .05; **P < .001.
