Skip to main content
. 2013 Mar 26;98(5):E943–E953. doi: 10.1210/jc.2012-4116

Figure 3.

Figure 3.

Prevalence of nonreproductive phenotypes and their relative enrichment within specific genetic groups. Six panels show the relative enrichment of synkinesia (A), dental agenesis (B), hearing loss (C), syndactyly/camptodactyly/polydactyly (D), renal agenesis (E), and cleft lip/palate (F) within specific genetic groups. In each panel, 2 histograms are shown: the larger histogram shows the percentage of probands with RSVs in a specific gene compared with probands negative for the gene (eg, in panel A, KAL1 probands vs non-KAL1 probands and likewise in panels B–F). The unadjusted OR for the enrichment of the relevant phenotype within the specific genetic group is shown in the top right hand corner of the panel. The smaller histogram in each panel displays the absolute percentage of probands displaying the phenotype within each individual genetic group. CHD7, CHD7; FGF, FGF8/FGFR1 signaling pathway; KAL1, KAL1; Neg, gene-negative group; non-KAL1, all probands without KAL1 mutations; non-FGF, all probands without FGF8/FGFR1 mutations; non-CHD7, all probands without CHD7 mutations; PROK, PROK2/PROKR2 signaling pathway. *P < .05 for KAL1 vs non-KAL1 (A); FGF vs Non-FGF (B and D); CHD7 vs Non-CHD7 (C).