Table 5.

Variants in the 15q25 gene cluster influence CHRNA5 gene expression in brain

SNPs	Allele	β	L_95	U_95	P
rs951266	T	−0.17	−0.33	−0.01	0.05
rs16969968	A	−0.33	−0.57	−0.09	0.007
rs1051730	A	−0.33	−0.57	−0.09	0.007
rs8040868	C	−0.14	−0.29	0.01	0.07
rs17487223	T	−0.22	−0.38	−0.06	0.005

The minor allele is associated with lower CHRNA5 gene expression for the nonsynonymous rs16969969 variant, the synonymous rs1051730 variant, and the rs17487223 intron. Results were obtained from a meta-analysis of three expression datasets (n = 332).

Significant P-values are represented in bold.

SNP, single nucleotide polymorphism.