Figure 6.

Diagram of CoTC and Pause-Type Pol II Termination Pathways

In the CoTC termination pathway transcripts of AT-rich terminator elements (red bar) are cleaved by CoTC activity (red scissors) promoting Pol II release before poly(A) site cleavage, mediated by the 3′ processing complex (green scissors). In the pause-type termination pathway, Pol II transcriptional pausing, at G-rich sequences (blue bar), enhances pre-mRNA cleavage at the poly(A) site, leading to Pol II release. Icons and symbols as in Figure 1A.