Figure S4.

Result of Search for Potential Novel Sequence Motifs Using MEME Software, Related to Results and Discussion

Putative CoTC terminator regions (2Kb downstream of the CLIP-seq sites for the 78 CoTC candidate genes) were analyzed for the presence of shared motifs using position specific priors based on a negative sequence set (2Kb downstream of annotated pA sites for 500 randomly selected protein coding genes). The top three motifs are shown, together with p-values and number of sequences in which they were found. While as expected several motifs are identified by this approach, their relevance is questionable as they only occur in a subset of candidates (‘zoops’ mode). No strong motif was present in all candidates (‘oops’ mode).