Figure 9.

Representative histopathological findings in infected lung tissue. The lung tissues were harvested at 24 and 48 hours after infection, fixed, and H&E stained for histological evaluation. A: Representative image of lungs of Splunc1^+/+ mice at 24 hours after infection. B: Representative image of lungs of Splunc1^−/− mice at 24 hours after infection. C: Representative image of lungs of Splunc1^+/+ mice at 48 hours after infection. D: Representative image of lungs of Splunc1^−/− mice at 48 hours after infection. Splunc1^−/− mice exhibited more significant peribronchial inflammation and airway lumen leukocyte accumulation and more severe pneumonia. Insets are enlarged regions of corresponding boxes in their respective figures. Scale bar = 50 μm.