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. Author manuscript; available in PMC: 2014 Apr 2.
Published in final edited form as: Structure. 2013 Apr 2;21(4):501–515. doi: 10.1016/j.str.2013.02.024

Figure 2. Domain architecture and structures of Apaf-1 like proteins in the NOD super-family.

Figure 2

A. Linear domain representations are shown for CED-4, Apaf-1 and Dark. This domain color scheme is used throughout.

B. A crystal structure is shown of the CED-9 inhibited CED-4 lateral dimer (2A5Y). The CARD in monomer B is disordered (Yan et al., 2005) and the boundary between monomers is indicated by a dashed line.

C. A composite model is shown for an inactive Apaf-1 monomer based on two crystal structures (Reidl et al., 2005; Reubold et al., 2011).