Skip to main content
. Author manuscript; available in PMC: 2014 Apr 2.
Published in final edited form as: Structure. 2013 Apr 2;21(4):501–515. doi: 10.1016/j.str.2013.02.024

Figure 7.

Figure 7

Possible conformational changes that occur during Apaf-1 assembly are shown with inactive and active conformations aligned on the NBD. Cytochrome c binding may trigger inter-domain rearrangements and motions that lead to nucleotide exchange. An extensive rearrangement of the NBD-HD1 module occurs relative to the rest of Apaf-1. This creates an extended and assembly competent conformation. Procaspase-9 may interact with the CARD in the Apaf-1 monomer during nucleotide exchange leading directly to the formation of a CARD-CARD disk as the platform assembles.