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Schematic diagram describing the proposed GSK3β–β-catenin–Akt axis involved in the dysregulated proinflammatory response. Cav1 knockout decreases β–catenin while increases GSK-3β expression, resulting in a decrease in Akt levels. This also downregulates STAT5 with and leads to decreased nuclear translocation, which may impact on production of cytokines such as TNF-α, IL-12a and IL-6, and infection outcome.
