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All affected members of this family have bilateral ophthalmic involvement. Subject ‘A’ underwent enucleation of one eye. Subject ‘B’, the proband, underwent radiotherapy and has a bicuspid aortic valve. Subject ‘C’ has a bicuspid aortic valve and no eye involvement by retinoblastoma. Subject ‘D’ received radiotherapy and cobalt plaque therapy. Subject ‘E’ received chemotherapy and cryotherapy. Subject ‘F’ has undergone cryotherapy.
