TABLE 1.
Demographics of the Patients With Head and Neck Squamous Cell Carcinoma Examined for CDH1 Hypermethylation (n=340)
| Characteristic | No. | Prevalence |
|---|---|---|
| Age, y | ||
| <50 | 68 | 20 |
| 50–59 | 115 | 33.8 |
| 60–69 | 85 | 25 |
| >70 | 72 | 21.2 |
| Sex | ||
| Women | 89 | 26.2 |
| Men | 251 | 73.8 |
| Pack-years smoked* | ||
| 0–5 | 82 | 24.9 |
| 5–34 | 99 | 31.1 |
| >34 | 148 | 45 |
| Average alcoholic drinks per wk† | ||
| 0–2.5 | 49 | 14.7 |
| 2.5–6 | 50 | 15 |
| 6–14 | 57 | 17 |
| >14 | 178 | 53.3 |
| HPV-16 seropositivity | ||
| Negative | 253 | 74.4 |
| Positive | 87 | 25.6 |
| CDH1 hypermethylation | ||
| Negative | 227 | 66.8 |
| Positive | 113 | 33.2 |
| Tumor stage‡ | ||
| 1 | 25 | 16.5 |
| 2 | 31 | 20.4 |
| 3 | 37 | 24.3 |
| 4 | 58 | 38.8 |
| Tumor site§ | ||
| Oral cavity and tongue | 194 | 57.4 |
| Pharynx | 86 | 25.4 |
| Larynx | 58 | 17.2 |
HPV-16 indicates human papillomavirus type 16; the CDH1, cadherin 1, type 1/E-cadherin gene.
*
Data on pack-years of smoking were missing for 11 individuals.
†
Data on alcohol consumption were missing for 6 individuals.
‡
The components used to derive tumor stage were not fully available for 188 patients.
§
Tumor site was not available for 2 patients.