TABLE 2.

Multivariate Analysis of Association Between Patient Demographics and CDH1 Hypermethylation^*

Characteristic	CDH1 Methylation Status: No. of Patients (%)		OR [95% CI]
	Negative	Positive
Age, y
<50	43 (63)	25 (37)	Referent
50–59	76 (66)	39 (34)	0.9 [0.5–1.7]
60–69	57 (67)	28 (33)	0.9 [0.4–1.7]
>70	51 (71)	21 (29)	0.7 [0.3–1.4]
Sex
Women	54 (61)	35 (39)	Referent
Men	173 (69)	78 (31)	0.7 [0.4–1.2]
Pack-years smoked
Never	38 (61)	24 (39)	1.4 [0.8–2.5]
>0–10	16 (50)	16 (50)	2.4 [1.1–5]†
>10	164 (70)	71 (30)	Referent
HPV-16 seropositivity
Negative	168 (66)	85 (34)	Referent
Positive	59 (68)	28 (32)	0.9 [0.5–1.6]

CDH1 indicates the cadherin 1, type 1/E-cadherin; OR, odds ratio; CI, confidence interval; HPV-16, human papillomavirus type 16.

^*Note: The model was controlled for all variables in the table. Eleven patients were missing data on smoking history; they were coded as missing and were included in the model.

^†P <.03.