Figure 10.

A 54-year-old woman with well-differentiated liposarcoma containing dedifferentiated components. (a) Axial contrast-enhanced CT image before the start of treatment demonstrates well-differentiated fat anteriorly (white arrows). The dedifferentiated component is seen as ill-defined soft tissue attenuation areas posteriorly (white arrowheads) with enhancing solid nodules (black arrow). (b) Axial contrast-enhanced CT image 12 months after treatment with trabectedin reveals replacement of the dedifferentiated component (white arrowheads) as well as the soft tissue nodule (black arrow) with fatty tissue suggestive of treatment effect or further differentiation in previously dedifferentiated components. The well-differentiated component (white arrow) is unchanged. (c) Axial CT image of the chest during the course of treatment when the patient developed an episode of fever and cough demonstrates interlobar interstitial thickening in the right lung base representing unilateral pulmonary edema, seen with capillary leak syndrome, a known complication of trabectedin therapy.