Figure 5.

A 78-year-old man with metastatic leiomyosarcoma. (a) Axial contrast-enhanced CT image demonstrates a lobulated heterogeneous mass along the left pelvic sidewall (arrow) representing metastatic disease. (b) Axial contrast-enhanced CT image after 6 months of treatment with pazopanib reveals increased size of the mass with a concurrent significant decrease in the density (arrow). (c) Axial contrast-enhanced CT image of the abdomen during an episode of acute abdominal pain during the course of treatment reveals a bulky and edematous pancreas with peripancreatic stranding consistent with acute pancreatitis (arrowhead), a class-specific drug toxicity of tyrosine kinase inhibitors (TKIs).