Table 2.
Single-Nucleotide Polymorphisms (SNPs) That Modified the Association of Low Vitamin D Concentration With Risk of Clinical Outcomes Among 1514 Participants in the Cardiovascular Health Study Discovery Cohort
| SNP | Genea | Substitutionb | MAF | Composite Outcome (n = 948)
|
HRR (95% CI)c
|
|||||
|---|---|---|---|---|---|---|---|---|---|---|
| HRR (95% CI)c | P Value | q Value | Death (n = 768) | MI (n = 214) | Hip Fracture (n = 178) | Cancer (n = 337) | ||||
| rs7968585 | VDR | T → C | 0.48 | 1.4 (1.1–1.7) | .002 | 0.18 | 1.3 (1.0–1.6) | 1.2 (0.8–1.9) | 1.2 (0.8–1.9) | 1.5 (1.1–2.2) |
|
| ||||||||||
| rs2239179 | VDR | G → A | 0.42 | 0.7 (0.6–0.9) | .008 | 0.18 | 0.8 (0.7–1.0) | 0.7 (0.5–1.1) | 0.9 (0.6–1.5) | 0.6 (0.4–0.9) |
|
| ||||||||||
| rs1801222 | CUBN | C → T | 0.32 | 1.4 (1.1–1.8) | .004 | 0.18 | 1.2 (0.9–1.5) | 1.4 (0.9–2.2) | 1.4 (0.8–2.4) | 1.3 (0.8–1.9) |
|
| ||||||||||
| rs12766939 | CUBN | A → G | 0.28 | 0.7 (0.6–0.9) | .007 | 0.18 | 0.8 (0.6–1.1) | 0.8 (0.5–1.3) | 0.5 (0.3–0.9) | 1.0 (0.6–1.5) |
|
| ||||||||||
| rs703842 | CYP27B1 | T → C | 0.31 | 0.7 (0.6–0.9) | .007 | 0.18 | 0.8 (0.6–1.0) | 0.8 (0.5–1.2) | 0.4 (0.2–0.8) | 0.8 (0.5–1.2) |
Abbreviations: HRR, hazard ratio ratio; MAF, minor allele frequency; MI, myocardial infarction.
a
The SNP is located within the gene ±20 kb.
b
Indicates allele substitution, with minor allele listed second.
c
The HRR (adjusted for age and sex) is the ratio for each additional minor allele of the hazard ratio describing the association between low 25-hydroxyvitamin D concentration and disease risk.