Table 3.
Replication Results in the Health ABC, InCHIANTI, and ULSAM Cohorts for the Interactions Between Low Vitamin D Concentration and Single-Nucleotide Polymorphisms (SNPs) on Risk of the Composite Outcome That Were Identified in the Cardiovascular Health Study (CHS) Discovery Cohort
| SNP | Genea | CHS HRRb | Health ABC
|
InCHIANTI
|
ULSAM
|
Meta-analysis
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Replicationc
|
Fulld
|
||||||||||||
| HRR (95% CI)b | P Value | HRR (95% CI)b | P Value | HRR (95% CI)b | P Value | HRR (95% CI)b | P Value | HRR (95% CI)b | P Value | P Valuee | |||
| rs7968585 | VDR | 1.40 | 1.14 (0.97–1.34) | .12 | 1.59 (1.01–2.51) | .04 | 1.12 (0.88–1.42) | .37 | 1.16 (1.02–1.32) | .02 | 1.22 (1.09–1.36) | <.001 | .24 |
|
| |||||||||||||
| rs2239179 | VDR | 0.74 | 0.95 (0.81–1.10) | .48 | 0.66 (0.41–1.05) | .08 | NA | NA | 0.91 (0.79–1.06) | .15 | 0.85 (0.76–0.97) | .01 | .11 |
|
| |||||||||||||
| rs1801222 | CUBN | 1.39 | 0.91 (0.77–1.08) | .29 | 0.70 (0.42–1.15) | .15 | 1.05 (0.81–1.36) | .70 | 0.93 (0.81–1.07) | .30 | 1.03 (0.92–1.16) | .58 | .01 |
|
| |||||||||||||
| rs12766939 | CUBN | 0.72 | 1.06 (0.88–1.28) | .52 | 1.26 (0.81–1.95) | .30 | 1.16 (0.87–1.54) | .32 | 1.11 (0.96–1.28) | .17 | 0.99 (0.87–1.12) | .84 | .02 |
|
| |||||||||||||
| rs703842 | CYP27B1 | 0.72 | 1.04 (0.89–1.21) | .65 | 0.99 (0.62–1.58) | .97 | 0.82 (0.62–1.08) | .16 | 0.98 (0.86–1.12) | .77 | 0.91 (0.81–1.02) | .12 | .07 |
Abbreviations: ABC, Aging and Body Composition; HRR, hazard ratio ratio; InCHIANTI; Invecchiare in Chianti; NA, data not available; ULSAM, Uppsala Longitudinal Study of Adult Men.
The SNP is located within the gene±20 kb.
The HRR (adjusted for age and sex) is the ratio for each additional minor allele of the hazard ratio describing the association between low 25-hydroxyvitamin D concentration and disease risk.
Estimates from replication cohorts only: Health ABC, InCHIANTI, and ULSAM (if data available).
All estimates (includes CHS results).
For heterogeneity.