Table 4.
Joint Associations of VDR Single-Nucleotide Polymorphisms and Low 25-Hydroxyvitamin D Concentration on Risk of the Composite Outcome in the Cardiovascular Health Study
| No. of Events | Person-Years | Incidence Rate (95% CI)a
|
Hazard Ratio (95% CI) for Low 25-Hydroxyvitamin Dc | |||
|---|---|---|---|---|---|---|
| Within Groups | Difference Between Groupsb | |||||
| rs7968585 | ||||||
| No minor alleles | ||||||
| Normal level of 25-hydroxyvitamin Dd | 193 | 2992 | 6.5 (5.6 to 7.4) |
|
−0.4 (−2.3 to 1.4) | 0.93 (0.70 to 1.24) |
|
| ||||||
| Low level of 25-hydroxyvitamin De | 54 | 895 | 6.0 (4.5 to 7.9) | |||
|
| ||||||
| 1 minor allele | ||||||
| Normal level of 25-hydroxyvitamin Dd | 374 | 5657 | 6.6 (6.0 to 7.3) |
|
2.3 (0.6 to 4.1) | 1.40 (1.12 to 1.74) |
|
| ||||||
| Low level of 25-hydroxyvitamin De | 111 | 1239 | 9.0 (7.4 to 10.8) | |||
|
| ||||||
| 2 minor alleles | ||||||
| Normal level of 25-hydroxyvitamin Dd | 167 | 2775 | 6.0 (5.1 to 7.0) |
|
4.1 (1.2 to 7.1) | 1.82 (1.31 to 2.54) |
|
| ||||||
| Low level of 25-hydroxyvitamin De | 49 | 482 | 10.2 (7.5 to 13.4) | |||
|
| ||||||
| rs2239179 | ||||||
| No minor alleles | ||||||
| Normal level of 25-hydroxyvitamin Dd | 250 | 3861 | 6.5 (5.7 to 7.3) |
|
3.4 (0.9 to 5.9) | 1.58 (1.19 to 2.11) |
|
| ||||||
| Low level of 25-hydroxyvitamin De | 66 | 669 | 9.9 (7.6 to 12.6) | |||
|
| ||||||
| 1 minor allele | ||||||
| Normal level of 25-hydroxyvitamin Dd | 364 | 5547 | 6.6 (5.9 to 7.3) |
|
2.3 (0.6 to 4.0) | 1.44 (1.17 to 1.77) |
|
| ||||||
| Low level of 25-hydroxyvitamin De | 116 | 1309 | 8.9 (7.3 to 10.6) | |||
|
| ||||||
| 2 minor alleles | ||||||
| Normal level of 25-hydroxyvitamin Dd | 120 | 2016 | 6.0 (4.9 to 7.1) |
|
−0.9 (−3.0 to 1.1) | 0.80 (0.55 to 1.18) |
|
| ||||||
| Low level of 25-hydroxyvitamin De | 32 | 638 | 5.0 (3.4 to 7.1) | |||
These unadjusted rates are reported as the number of events per 100 person-years and the 95% CIs are Poisson-based.
Computed as incidence rate in participants with low 25-hydroxyvitamin D levels minus the incidence rate in those with normal 25-hydroxyvitamin D levels.
Risk of the composite outcome in participants with low 25-hydroxyvitamin D vs risk in those with normal 25-hydroxyvitamin D; the HRs were adjusted for age and sex.
Defined as above the season-specific 20th percentile of 25-hydroxyvitamin D levels.
Defined as below the season-specific 20th percentile of 25-hydroxyvitamin D levels.