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. Author manuscript; available in PMC: 2014 Apr 1.
Published in final edited form as: Cancer Epidemiol Biomarkers Prev. 2013 Mar 5;22(4):485–495. doi: 10.1158/1055-9965.EPI-13-0010

Figure 1. Multi-level Biological And Social Integrative Construct (MBASIC) (MBASIC).

Figure 1

This framework includes levels of etiology, carcinogenesis, intervention, and implementation/evaluation, as well as previously defined phases of translation (i.e., T0-T4; (36, 37). Biological levels include inherited genome (IG), somatic genome (SG), as well as related biomarkers of biologically effective dose (BED), biomarkers of early biological effect (EBE), and biomarkers of altered structure and function (ASF) (41).