Fig. 4.

TRPM8^−/− mice do not show enhanced DSS-induced colonic inflammation but have elevated levels of CGRP. Assessment of intestinal damage scores, colonic MPO levels, and bowel thickness in WT and TRPM8^−/− mice treated with vehicle, DSS (2.5% wt/vol), or low-dose DSS (1% wt/vol:Low DSS). TRPM8^−/− mice do not show significantly different (A) damage scores, (B) bowel thickness, or (C) MPO levels compared with WT mice. (D) Comparison of CGRP levels in colonic tissue from WT and TRPM8^−/− mice after 7 d of DSS administration. Data are shown as mean ± SEM. n = 8 animals per group. *P < 0.05.