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Mre11-Rad50-Xrs2 complex stimulates resection of dsDNA by Exo1. (A) A representative experiment with blunt-ended pUC19 dsDNA (1 nM, 32P labeled at the 3′ end) showing degradation by Exo1 (0.4 nM, where indicated) and its stimulation by MRX [1, 3, 10, 30, and 100 nM (lanes 2–6) and 1, 3, 10, and 30 nM (lanes 8–11), respectively]. (B) Reaction as in A carried out in the presence of RPA (0.4 μM). (C) Quantitation of experiments as in A and B. Error bars show SE.
