Fig. 1.

P2RX2-null mice (KO) lacked TTS in response to moderate-intensity noise evident in WT controls. (A) Examples of ABR traces (10-ms duration) for click stimuli before and after 30-min noise (85 dB, closed-field). The threshold in the WT mouse increased from 32.5 dB to 45 dB (blue bar), whereas the P2RX2-null mouse threshold remained unchanged (red bar). (B) Box plots with data overlay showing the pre- and postnoise thresholds assessed using click and 16-kHz tone pip stimuli (***P < 0.001; ns, P > 0.05; n = 9 WT; n = 7 KO). Tests were within ∼30 min postnoise exposure. Dashed lines show the means.