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Amino acid alignment of the α-repeats. (A) Intramolecular similarity between TMS2 and -7 of the α-repeats of NCX1.1. Conserved residues are shown in bold. Mutated residues used in this study are underlined. The GXXXP motif is boxed. (B) Sequence alignment between the archaebacterial NCX_Mj and the mammalian NCX1.1 exchangers TMS2 and -7. Conserved residues are in bold, and residues coordinating Na+ and Ca2+ in NCX_Mj are marked with an asterisk.
