Fig. 3.

Deficiency of β-arrestin1 ameliorates CIA. (A and B) Incidence (A) and severity (B) of CIA in Arrb1^−/− mice and WT littermates (n = 15 per group). *P < 0.05 and **P < 0.01, versus WT littermates. (C and D) Hematoxylin and eosin (H&E) staining (C) and safranin O staining (D) of paraffin sections of ankle joints at day 56 after initial immunization (n = 8 per group). (E) Representative photograph and radiography of the hind paws (n = 8 per group). (F) Expression of various cytokines in the joints of collagen II (CII)-immunized Arrb1^−/− mice and WT littermates (n = 8 per group).