Fig. 4.

Identification of a DOCK1-null gene signature enriched in IFN response genes. (A) Heat map of the 45 genes differentially expressed between NIC⁺DOCK1^wt/wt and NIC⁺DOCK1^flx/flx tumors. Red, elevated; green, decreased; intensity of color represents relative change. Genes in red are bona fide players of IFN signaling according to the literature. (B) Gene ontology analyses. (C) Expression levels of a subset of genes from the NIC⁺DOCK1^flx/flx signature correlate with disease-free survival in human HER2⁺ breast cancer patients. Correlation coefficient >1 means high expression of the gene correlate with a poor prognostic and <1 with a good prognostic. (D) Expression levels of RTP4 and STAT1 independently predict disease-free survival in HER2⁺ cancer patients.