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. 2013 Mar 26;14(4):6690–6719. doi: 10.3390/ijms14046690

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© 2013 by the authors; licensee MDPI, Basel, Switzerland

This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).

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Schematic representation of Sip1 and OAZ domain structures. Sip1 contains two clusters of zinc fingers (NZF and CZF) that flank a centrally located homeodomain-like domain (HD). Between the HD and the CZF cluster, there is a segment containing 4 CtBP co-repressor interacting sequences (forming the CtBP-interacting domain, CID). Sip1 also binds the chromatin remodeling co-repressor NuRD. Sip1 is post-translationally modified by sumoylation (SUMO; exerted by Pc2). Sip1 contains a R-Smad-binding domain (SBD). OAZ contains 30 zinc fingers spread over clusters, mediating binding with DNA (to CGACC), a BMP–Smad-responsive element (BRE), Smad1/4 and Olf-1/Ebf-1 proteins (For more details, see main text).