Table 2.
Intracellular signaling cascades triggered by mitochondrial peptides.
| Ligands | Origin | Selectivity | Cells | Effects | Ref. | Potency |
|---|---|---|---|---|---|---|
| f-MLKLIV | Mitochondria | FPR1, FPR2 | FPR-transfected HL60 |
chemotaxis; Ca2+ mobilization; ERKs activation | [8] | pEC50 = 7.92, 7.26 |
| f-MMYALF | Mitochondria | FPR2 > FPR1 | FPR-transfected HL60 |
chemotaxis; O2−. generation | [8] | pEC50 = 7.82, 7.92 |
| MCT-2 | Mitochondria | FPR2 | Neutrophils; Granulocytes | chemotaxis; Ca2+ mobilization; ERKs activation β-hexosaminidase release |
[18] | EC50 = 240 nM |
pEC50 = negative logarithm of the EC50.