Table 9.
Intracellular signaling cascades triggered by other ligands from peptide library.
| Ligand | Origin | Selectivity | Cells | Effects | Ref. | Potency |
|---|---|---|---|---|---|---|
| MMK-1 | Peptide library | FPR2 | Neutrophils; Monocytes | Ca++ mobilization; chemotaxis; NADPH oxidase activation | [136,137] | pEC50 = 8.70 |
| CGEN-855A | Peptide library | FPR2, FPR3 | FPR2/3-expressing cells | Ca++ mobilization; increase of cell impedance index; anti-inflammatory | [140] | IC50 = 189 nM Ki = 54.1 nM |
| MMHWAM | Peptide library | FPR2 | Neutrophils; Monocytes | Ca++ mobilization; chemotaxis; PLC activation; NADPH oxidase activation | [141] | - |
pEC50, negative logarithm of the EC50.