Table 3.
Scavenger | IC50 (μM) | Scavenger | IC50 (μM) |
---|---|---|---|
Glutathione | 31 ± 2.5 | Methionine | 185 ± 7 |
Ascorbate | *** | Uric acid | 400/26 ± 2 * |
2,6-Dithiopurine | 40 ± 5 ** | 2,6-Dithiopyrimidine | 45 ± 8 ** |
Ebselen | *** | 3,7-Dimethyluric acid | 400/42 ± 1.5 * |
Se-methionine | 15 ± 1 | Tryptophan | 400/35 ± 3 * |
Cysteine | 18 ± 3 | Tyrosine | 420 ± 30 |
highest concentration of scavenger/percentage of preserved ADH-activity at this concentration;
scavenger itself reduced ADH-activity by 20% when used at 50 μM;
strong inhibition of ADH by ebselen and probably a product from the peroxynitrite-ascorbate reaction.