Table 2.

Altered lipid metabolism in ovarian cancer: potential therapeutic targets.

Target	Treatment	Effect	References
Cholesterol	Statins	Induce apoptosis of ovarian cancer cells. In clinical trials.	[85,86]
FAS	C93	Increases cytotoxicity of carboplatin and paclitaxel. Induces cell death in vitro and reduces tumour growth in xenograft mouse model.	[25,29]
	C75	Reduces cell proliferation in ovarian clear cell carcinoma cell lines. Inhibits growth and survival of ovarian cancer cells in vitro.	[30,31]
ATX	ccPA	Increases cytotoxicity of carboplatin.	[90]
ENPP2	siRNA	Increases apoptosis of cancer cells with carboplatin.	[90]
Ceramide	Ceramide	Co-administration with the chemotherapy drugs, paclitaxel or carboplatin, sensitises cancer cells, increasing cell death.	[87]
CERT	siRNA	Sensitises cancer cells to paclitaxel.	[88]

Abbreviations: Fas, fatty acid synthase; ATX, autotaxin; ccPA, 2-carbacyclic phosphatidic acid; ENPP2, ectonucleotide pyrophosphatase/phosphodiesterase 2; CERT, ceramide transport protein.