Table 1.
Cq values for miRNAs that show similar trends in expression differences in plasma from patients with localized PCa versus mCRPC and in non-metastatic versus metastatic tumor tissue.
| Increased miRNA | Localized | mCRPC | Notes 1 |
|---|---|---|---|
| miRNA-125b-2 * | ND | 33.88 | >2 |
| miRNA-136 | 34.58 | 31.35 | >2 |
| miRNA-151-3p | 31.61 | 29.26 | >2 |
| miRNA-200a | 34.27 | 31.52 | >2 |
| miRNA-744a * | 38.09 | 34.51 | >2 |
| miRNA-9 | 39.09 | 34.79 | >2 |
| miRNA-9 * | ND | 34.12 | >2 |
| miRNA-99a | 34.28 | 32.02 | >2 |
| Let-7d | 33.21 | 31.37 | >1 |
| miRNA-126 | 26.49 | 24.93 | >1 |
| miRNA-142-5p | 30.35 | 29.16 | >1 |
| miRNA-18b | 30.14 | 28.98 | >1 |
| miRNA-27a | 29.07 | 27.31 | >1 |
| miRNA-27b | 29.15 | 27.25 | >1 |
| miRNA-30a * | 35.48 | 34.33 | >1 |
| Decreased miRNA | Local | mCRPC | Notes |
| miRNA-205 | 32.43 | 34.90 | >2 |
| miRNA-106b | 30.38 | 31.50 | >1 |
| miRNA-16 | 22.64 | 23.97 | >1 |
| miRNA-363 | 29.93 | 31.08 | >1 |
1
>2 or >1 refer to Cq differences in expression in the mCRPC versus localized PCa group (Supplemental Table S1). miRNAs showed increased or decreased expression in a metastatic prostate tumor xenograft model, as described previously [16].