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. 2013 Apr 16;14(4):8291–8305. doi: 10.3390/ijms14048291

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© 2013 by the authors; licensee MDPI, Basel, Switzerland

This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).

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The tissue was histologically evaluated on day 6 after administration. (A) GFP was expressed within the corneal intrastromal layer and keratocytes after the implantation of p-GFP-SAINT-18. No vascular lumen was noted; (B) The intervening stroma displayed cells, edema, a mononuclear inflammatory response, and numerous vascular lumens (indicated by arrows) after hematoxylin and eosin staining in the corneal and subconjunctival substantia propria (100× magnification); (C) Inflammation was detected by the presence of macrophages and other inflammatory cells, such as lymphocytes, by immunohistochemical staining (anti-rat HLA-DR antibody) in the corneal and subconjunctival substantia propria (100× magnification).