. Author manuscript; available in PMC: 2013 May 6.

Published in final edited form as: Nat Rev Rheumatol. 2012 Sep 4;8(10):610–621. doi: 10.1038/nrrheum.2012.144

Table 2.

SLC2A9, ABCG2 and SLC22A12 variants associated with serum uric acid levels, FeUA and gout

Variant	Location	Phenotype	Populations
*SLC2A9 (chromosome 4)*
rs1014290	Intron 3	SUA, FeUA, gout	European ancestry³⁴
rs6449213	Intron 4	SUA, FeUA, gout	White,^34–37,43 African American^51,72
rs16890979	Exon 6	SUA, gout	White,^37,42,44 African American,⁷² Amish⁵⁵
rs734553	Intron 6	SUA, gout	White,^32,39,44 Icelandic,¹³ African American⁷²
rs7442295	Intron 6	SUA, gout	White ^35,38,39,44
rs737267	Intron 7	SUA, FeUA, gout	European ancestry^34,44
rs6855911	Intron 7	SUA, gout	White,^35,38,39,44 African American⁷²
rs13129697	Intron 7	SUA, gout	White,^33,44 African American⁷²
rs2241480	Intron 8	SUA, gout	European ancestry⁷²
rs7663032	Intron 9	SUA, gout	African American,⁷² Croatian⁴⁴
rs3775948	Intron 9	SUA	Croatian,⁴⁴ African American⁵¹
rs16890979	Intergenic	SUA, gout	White,³⁷ Amish,⁵⁵ Croatian,⁴⁴ Pacific Islander,⁴² New Zealander⁴²
rs717615	Intergenic	SUA	Croatian⁴⁴
rs6856396	Intergenic	SUA	African American⁵¹
rs10489070	Intergenic	Gout	Amish⁵⁵
*ABCG2 (chromosome 4)*
rs2231137	Exon 2	SUA	Japanese⁶³
rs72552713 (Q126X)	Exon 4	SUA, gout	Japanese⁶³
rs2231142 (Q141K)	Exon 5	FeUA, SUA, gout	White,^{32,37,39,44,62} African,^37,72 Chinese,⁶⁰ Icelandic,¹³ Japanese,^59,63 Pacific Islander,⁶¹ New Zealander^31,61
rs2199936	Intergenic	SUA	White ^32,33,44
*SLC22A12 (chromosome 11)*
rs11231825	Exon 1	FeUA, SUA	Chinese,⁷⁰ White,^32,68 African American⁷²
rs3825016	Exon 2	FeUA	German⁶⁸
rs12800450	Exon 2	SUA	African American⁷²
rs161109885	Intron 3	SUA	Chinese⁷³
rs893006	Intron 4	SUA	Japanese,⁶⁷ Chinese⁷¹
rs1529909	Intron 4	FeUA, SUA	Korean⁷⁴
rs475688	Intron 4	Gout	Chinese,⁷⁰ Solomon Islander⁷⁰
rs17300741	Intron 4	SUA	European^32,75
rs7932775	Exon 8	SUA, FeUA, gout	German,⁶⁸ Chinese,^70,73 Solomon Islander⁷⁰
rs505802	Intergenic	SUA	European,^32,44 African American⁷²
rs11602903	Intergenic	FeUA, SUA	German,⁶⁸ Chinese⁷³

Abbreviations: FeUA, fractional excretion of urate; SUA, serum uric acid.