Table 4.
Variant | Phenotype | Potential functional mechanism | Populations |
---|---|---|---|
ADRB3 (chromosome 8) | |||
Trp64Arg | SUA | Might cause reduced lipolysis and increased adipose tissue that could result in insulin resistance | Korean,88 Spanish,87 Italian,95 Japanese,89 Chinese95 |
rs4994 | Gout | Unknown | Chinese94 |
MTHFR (chromosome 1) | |||
Cys677Thr | SUA | Might cause increased de novo synthesis of purines | Japanese,90,92 Korean,91 Iranian,118 Brazilian93 |
PRKG2 (chromosome 4) | |||
rs10033237 | Gout | Might cause increased renin activity | Taiwanese96 |
rs7688672 | Gout | Might cause increased renin activity | Taiwanese96 |
rs6837293 | Gout | Might cause increased renin activity | Taiwanese96 |
SGK1-SLC2A12 Locus (chromosome 6) | |||
rs9321453 | SUA | Unknown | European ancestry, African American72 |
ALDH16A1 (chromosome 19) | |||
Cg1580C>G | SUA, gout | Might be involved in purine metabolism | Icelandic13 |
Chr 1-centromere (chromosome 1) | |||
Chr1_142697422 | SUA, gout | Unknown | Icelandic13 |
TGFB1 (chromosome 19) | |||
869T/C | Tophi formation | Might regulate local inflammatory responses and/or tophi formation | Taiwanese97 |
Abbreviation: SUA, serum uric acid.