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. Author manuscript; available in PMC: 2013 May 6.
Published in final edited form as: Science. 2010 Jan 15;327(5963):291–295. doi: 10.1126/science.1183021

Fig. 4.

Fig. 4

Proposed consequences of Toll like receptor (TLR) recognition of exogenous versus endogenous ligands. TLR engagement by exogenous (A) or endogenous (B) agonists leads to signaling from distinct subcellular compartments (indicated by blue and green, respectively) and/or engagement of coreceptors. Consequently, exogenous ligands induce transcription of genes leading to inflammation, tissue repair and the initiation of adaptive immunity (A). In contrast, endogenous ligands induce TLR signaling for activation of inflammation and tissue repair but not the initiation of adaptive immunity (B).