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. Author manuscript; available in PMC: 2014 Apr 1.
Published in final edited form as: J Neurochem. 2013 Feb 17;125(1):16–25. doi: 10.1111/jnc.12150

Figure 5. Y1 and Y5 receptors do not regulate NPY expression in the adrenal medulla.

Figure 5

Examples of NPY-ir in sections of adrenal medulla from control mice or after i.p. injection with Y1 and Y5 antagonists. (A). Under basal, non-stressed conditions BIBP3226 did not alter the levels of NPY-ir in the adrenal medulla. (B). BIBP3226 also did not prevent the increase in NPY-ir that occurred following exposure to the cold FST. (C, D). NPY-ir in the adrenal medulla from control mice or after injection with L-152,804 (a Y5 antagonist) showing that L-152,804 did not alter the levels of NPY-ir under non-stressed conditions or prevent the stress-induced increase in NPY-ir. Left cumulative distribution in each panel shows NPY-ir from all cryosections (bin width 50 intensity units). Right histograms indicate the mean ± SEM (n = 3 independent experiments; 8 - 10 cryosections per animal). Open circles indicate the average value from each animal. Black lines link the matched control and stressed animals from each independent experiment. Scale bars 100 μm. ns = not significant.