Table 1.

Criterion for sleep regulatory substance.

Criterion For Sleep Regulatory Substance
In the brain, these sleep regulatory substances proclivity. and/or their receptors oscillate with sleep/wake In the brain, these sleep regulatory substances
Sleep increases or decreases when sleep regulatory substances are injected locally into the central nervous system or systemically.
The inhibition or removal of sleep regulatory substances changes sleep.
Sleep is altered by sleep regulatory substances in response to pathogens.