Table 3.
Diagnostic performance
| Variables | AUC (with 95% CI in parentheses) |
Cut-off | Accuracy
|
|||
|---|---|---|---|---|---|---|
| SE | SP | PPV | LR+ | |||
| AD versus HC | ||||||
| MMSE | 0.988 (0.976–0.999)*** | 24/25 | 85.6 | 100.0 | 100.0 | – |
| CDT-command | 0.912 (0.871–0.952)*** | 8/9 | 82.9 | 87.8 | 95.3 | 6.8 |
| CDT-copy | 0.764 (0.700–0.829)*** | 10 | 55.5 | 95.9 | 97.6 | 13.5 |
| ADAS-J cog | 0.989 (0.979–1.000)*** | 7.5/7.6 | 95.2 | 100.0 | 100.0 | – |
| MMSE + CDT-command | 0.997 (0.987–1.000)*** | 0.39 | 91.1 | 100.0 | 100.0 | – |
| AD versus MCI | ||||||
| MMSE | 0.795 (0.730–0.860)*** | 23/24 | 74.7 | 68.3 | 85.2 | 2.4 |
| CDT-command | 0.711 (0.630–0.792)*** | 8/9 | 74.0 | 58.3 | 81.2 | 1.8 |
| CDT-copy | 0.686 (0.614–0.759)*** | 10 | 55.5 | 75.0 | 84.4 | 2.2 |
| ADAS-J cog | 0.806 (0.741–0.871)*** | 13.5/13.6 | 75.3 | 71.7 | 86.6 | 2.7 |
| MMSE + CDT-copy | 0.811 (0.747–0.875)*** | 0.67 | 75.3 | 70.0 | 85.9 | 2.5 |
| MCI versus HC | ||||||
| MMSE | 0.837 (0.761–0.912)*** | 26/27 | 63.3 | 95.9 | 95.0 | 15.4 |
| CDT-command | 0.717 (0.622–0.812)*** | 8/9 | 50.0 | 87.8 | 83.4 | 4.1 |
| CDT-copy | 0.606 (0.501–0.711) | – | – | – | – | – |
| ADAS-J cog | 0.893 (0.831–0.955)*** | 13.5/13.6 | 80.0 | 87.8 | 88.9 | 6.6 |
Notes: Values are AUC (with 95% CI in parentheses).
***
P < 0.001.
Abbreviations: AUC, area under the curve; CI, confidence interval; SE, sensitivity; SP, specificity; PPV, positive predictive value; LR+, likelihood positive ratio; AD, Alzheimer’s disease; HC, healthy controls; MMSE, Mini-Mental State Exam; CDT, Clock Drawing Test; ADAS-J cog, Japanese version of the Alzheimer’s Disease Assessment Scale-cognitive subscale; MCI, mild cognitive impairment.