Table 1.
Histone readers and their target PTMs
| Recognition of | Reader | Histone PTM |
|---|---|---|
| Methyllysine | ADD | H3K9me3 |
| Ankyrin | H3K9me2, H3K9me1 | |
| BAH | H4K20me2 | |
| Chromobarrel | H3K36me3, H3K36me2, H4K20me1, H3K4me1 | |
| Chromodomain | H3K9me3, H3K9me2, H3K27me3, H3K27me2 | |
| DCD | H3K4me3, H3K4me2, H3K4me1 | |
| MBT | H3Kme1, H3Kme2, H4Kme1, H4Kme2 | |
| PHD | H3K4me3, H3K4me2, H3K9me3 | |
| PWWP | H3K36me3, H4K20me1, H4K20me3, H3K79me3 | |
| TTD | H3K4me3, H3K9me3, H4K20me2 | |
| Tudor | H3K36me3 | |
| WD40 | H3K27me3, H3K9me3 | |
| zf-CW | H3K4me3 | |
| Methylarginine | ADD | H4R3me2s |
| Tudor | H3Rme2, H4Rme2 | |
| WD40 | H3R2me2 | |
| Acetyllysine | Bromodomain | H3Kac, H4Kac, H2AKac, H2BKac |
| DBD | H3KacKac, H4KacKac | |
| DPF | H3Kac | |
| Double PH | H3K56ac | |
| Phosphoserine or phosphothreonine | 14-3-3 | H3S10ph, H3S28ph |
| BIR | H3T3ph | |
| Tandem BRCT | H2AXS139ph | |
| Unmodified histone | ADD | H3un |
| PHD | H3un | |
| WD40 | H3un |