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. 2013 May 6;8(5):e61479. doi: 10.1371/journal.pone.0061479

Figure 6. Sequence extension and gene discovery in the G. bimaculatus Hedgehog and Hippo pathways.

Figure 6

(A) The de novo transcriptome assembly of G. bimaculatus newly identifies most members of the hedgehog pathway (red), from which only the hedgehog ligand (blue) was previously known (GenBank accession AB044709). (B) The transcriptome also adds significant sequence data to the fragments of many genes in the Hippo signaling pathway that had been previously identified (green). Seven genes of the known pathway were not identified in the transcriptome (yellow, white), two of which lack any sequence data in GenBank (white). GenBank accessions for previously identified sequences are as follows: discs overgrown (dco): AB443442; expanded (ex): AB378099; warts (wts): AB300574; cyclin E (cycE): AB378067; hippo (hpo): AB378070; inhibitor of apoptosis protein (diap1): AB378071; mob as tumor suppressor (mats): AB378072; yorkie (yki): AB378076; scaffold protein salvador (sav): AB378074; Merlin (Mer): AB378073; Kibra: DC445461.