Figure 1. (A) Speed-stability paradox. (B) The search and recognition modes found in the DNA-scanning process of the zinc-finger protein Egr1. In the search mode, a zinc finger (red) is mainly dissociated while the other zinc fingers (green and yellow) are nonspecifically bound to DNA. In the recognition mode, all zinc fingers are in contact with DNA. (C) Intersegment transfer observed in the coarse-grained molecular dynamics simulations.