. Author manuscript; available in PMC: 2014 Apr 7.

Published in final edited form as: J Theor Biol. 2012 Dec 7;322:17–32. doi: 10.1016/j.jtbi.2012.11.018

Table 1.

Interactions for the basic inflammatory cascade.

$m + b \overset{k_{m b}}{\to} m_{a} + b$	macrophage activation by bacteria
$m + c \overset{k_{m c}}{\to} m_{a}$	macrophage activation by cytokines
$m + d \overset{k_{m d}}{\to} m_{a} + d$	macrophage activation by DAMPs
$n + c \overset{k_{n c}}{\to} n_{a}$	neutrophil activation by cytokines
$n + d \overset{k_{n d}}{\to} n_{a} + d$	neutrophil activation by DAMPs
$b + m_{a} \overset{k_{b m_{a}}}{\to} m_{a}$	bacteria destruction by macrophages
$b + n_{a} \overset{k_{b n_{a}}}{\to} n_{a}$	bacteria destruction by neutrophils
$c \overset{k_{d c}}{\to} d + c$	cytokine production of damage
$e_{c} \overset{k_{p}}{\to} 2 e_{c}$	proliferation of epithelial cells
$e_{c} + n_{a} + b + c \overset{k_{a}}{\to} n_{a} + b + c$	apoptosis of epithelial cells
$e_{c} \overset{k_{Z e_{c}}}{\to} Z O 1$	tight junction production
$Z O 1 + N O \overset{k_{Z N}}{\to} N O$	tight junction destruction
$m_{a} \overset{k_{N O m_{a}}}{\to} m_{a} + N O$	macrophage nitric oxide production
$n_{a} \overset{k_{N O n_{a}}}{\to} n_{a} + N O$	neutrophil nitric oxide production
$m_{a} \overset{k_{c m_{a}}}{\to} m_{a} + c$	macrophage production of cytokines
$n_{a} \overset{k_{c n_{a}}}{\to} n_{a} + c$	neutrophil production of cytokines
$\partial e_{c} ∕ \partial t \overset{k_{Z e_{c t}}}{\to} Z O 1$	tight junction production/destruction