Table 3.
Parameters describing rates of growth and interaction
| Parameter | Value | Units | Description |
|---|---|---|---|
| kb | 1.5 | h−1 | Decay rate of bacteria |
| kbg | 0.9 | h−1 | Growth rate of bacteria (varies for different bacteria) |
| kbma | 1.8 | (ma-units)−1h−1 | Rate of bacterial destruction by activated macrophages |
| kbna | 1.8 | (na-units)−1h−1 | Rate of bacterial destruction by activated neutrophils |
| kc | 1 | h−1 | Cytokine decay rate |
| kca | 0.1 | h−1 | Anti-inflammatory cytokine decay rate |
| kcamad | 48 | ma-units/d-units | Relative effectiveness of d and ma in producing ca |
| kcamana | 0.25 | ma-units/na-units | Relative effectiveness of na and ma in producing ca |
| kcap | 0 or 0.04 | ca-units/h | Production rate of ca by inflammatory cells |
| kcaQ | 1 | ma-units | Constant controlling how quickly production of ca saturates |
| kcma | 0.2 | (ma-units)−1h−1 | Rate at which macrophages produce cytokines |
| kcna | 0.05 | (na-units)−1h−1 | Rate at which neutrophils produce cytokines |
| kd | 0.02 | h−1 | Rate of decay of damage/DAMPs |
| kdc | 0.35 | (d-units)/h | Rate of damage/DAMP production by cytokines |
| kecnab | 0.25 | na-units/b-units | Relative effectiveness of b and na in killing ec |
| kecnac | 0.5 | na-units/c-units | Relative effectiveness of c and na in killing ec |
| km | 0.12 | h−1 | Resting macrophage decay rate |
| kma | 0.05 | h−1 | Activated macrophage decay rate |
| kmb | 0.1 | (106 bacteria/cm3)−1h−1 | Rate of macrophage activation by bacteria |
| kmc | 0.076 | (c-units)−1h−1 | Rate of macrophage activation by inflammatory cytokines |
| kmd | 0.02 | (d-units)−1h−1 | Rate of macrophage activation by DAMPs |
| kna | 0.05 | h−1 | Activated neutrophil decay rate |
| knc | 0.04 | (c-units)−1h−1 | Rate of neutrophil activation by inflammatory cytokines |
| knd | 0.018 | (d-units)−1h−1 | Rate of neutrophil activation by DAMPs |
| kNO | 2 | h−1 | Decay rate of nitric oxide |
| kNOma | 1×105 | (NO-units)h−1(ma-units)q1 | Rate at which activated macrophages induce NO production |
| kNOna | 1×105 | (NO-units)h−1(na-units)q1 | Rate at which activated neutrophils induce NO production |
| kp | 0.25 | h−1 | Rate of proliferation of epithelial cells |
| kpp | 0-0.25 | h−1 | Destruction rate of bacteria by peptides in breast-milk |
| kRca | 1 | Anti-inflammatory cytokine effect on damage/DAMP production | |
| kZec | 0.03 | (ec-units)−1h−1 | Rate of increase of ZO1 by epithelial cells |
| kZect | 2 | (ec-units)−1 | Rate of change of ZO1 induced by ec growth or decay |
| kZN | 0.75 | (NO-units)−1h−1 | Rate of destruction of tight junction protein, ZO1, by NO |