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Interleukin-6 interaction with its receptor complex. A: Mechanism of action of the interleukin-6 (IL-6); B: Activation of the two pathways triggered by the IL-6 action. SHP-2: Src homology 2 domain-containing protein tyrosine phosphatase-2; ERK/MAPK: Extracellular-signal-regulated kinase/mitogen-activated protein kinase; JAK/STAT: Janus associated kinase/signal transducer and activator of transcription.
