Table 2.
Multivariate survival analysis (Cox proportional hazards model) in gastrointestinal stromal tumors
| Variable | B | Wald | df | P value | HR |
95%CI for HR |
|
| Lower | Upper | ||||||
| Age | 0.023 | 1.696 | 1 | 0.193 | 1.024 | 0.988 | 1.060 |
| Sex | -0.239 | 0.342 | 1 | 0.559 | 0.788 | 0.354 | 1.754 |
| Mucosal erosion or not | 1.485 | 2.115 | 1 | 0.146 | 4.416 | 0.597 | 32.684 |
| Biopsy or not | -0.404 | 0.901 | 1 | 0.340 | 0.668 | 0.291 | 1.531 |
| CD34 | -0.071 | 0.086 | 1 | 0.769 | 0.932 | 0.582 | 1.493 |
| CA II | -0.319 | 4.113 | 1 | 0.043 | 0.727 | 0.543 | 0.989 |
| CD117 | -0.609 | 4.114 | 1 | 0.042 | 0.544 | 0.303 | 0.978 |
| Ki-67 | 1.103 | 7.282 | 1 | 0.007 | 3.014 | 1.352 | 6.717 |
| Diameter | 1.645 | 4.974 | 1 | 0.026 | 5.182 | 1.216 | 22.085 |
| Mitotic rate | 0.972 | 11.081 | 1 | 0.001 | 2.644 | 1.491 | 4.686 |
| Site | 1.334 | 15.581 | 1 | 0.000 | 3.796 | 1.955 | 7.371 |
| Depth of invasion | 0.559 | 7.445 | 1 | 0.006 | 1.748 | 1.170 | 2.612 |
| Complete resection or not | 2.807 | 24.674 | 1 | 0.000 | 16.555 | 5.470 | 50.104 |
| Intraoperative rupture | 1.937 | 17.997 | 1 | 0.000 | 0.144 | 0.059 | 0.353 |
| Adjuvant therapy | 1.757 | 35.579 | 1 | 0.000 | 5.796 | 3.254 | 10.325 |
This table shows that carbonic anhydrase (CA) II, CD117 and Ki-67 expression, tumor diameter, mitotic rate, tumor site, depth of invasion, complete resection, intraoperative rupture, and adjuvant therapy were important prognosis predictive factors. HR: Hazard ratios.